NAD+ Nasal Spray — Cellular Energy, Compounded for the Individual
A high-potency 300 mg/mL intranasal NAD+ formulation designed to support mitochondrial function, healthy aging, and cellular energy — compounded specifically for your patient's needs by a 503A-licensed pharmacy.
NAD⁺ Nasal Spray is a prescriber-directed, patient-specific intranasal formulation of nicotinamide adenine dinucleotide, compounded by Genesis Compounding as a 503A preparation for individual patients. Designed for convenient self-administration as a daily maintenance or adjunct regimen, this intranasal spray delivers NAD⁺ across the nasal mucosal epithelium, with potential for both systemic and direct nose-to-brain (olfactory) transport pathways. The strength per actuation is determined by the prescriber's specific order. This preparation is not FDA-approved.
| Active Ingredient | Pharmacologic Role |
|---|---|
| NAD⁺ (strength per actuation per prescriber order) | Endogenous redox coenzyme and sirtuin substrate; delivered intranasally to support systemic and CNS NAD⁺ repletion, maintaining mitochondrial energy metabolism, DNA repair, and cellular homeostasis as a maintenance delivery method. |
Intranasal spray: Prime the pump before first use per label instructions (typically 3–4 primes until an even mist appears). Tilt the head slightly forward. Insert the nasal tip into one nostril, gently occlude the other, and actuate while inhaling softly. Alternate nostrils per prescriber instructions. Avoid blowing the nose for 5–10 minutes after administration to allow mucosal absorption. Clean the nasal tip after each use. Store upright between uses. Administer the number of sprays and at the frequency specified on the prescription label.
All dosing — including number of sprays per administration, per nostril, and per day — is prescriber-determined based on the patient's clinical goals and the strength of the compounded preparation.
Identical to general NAD⁺ mechanism (ID 154). The intranasal route allows NAD⁺ to be absorbed through the nasal mucosa vasculature into systemic circulation, and potentially via the olfactory nerve sheath into CNS compartments, providing targeted brain delivery. This route bypasses GI degradation that limits oral NAD⁺ precursor bioavailability.
Prescribed as a daily maintenance strategy to sustain NAD⁺ levels between IV infusion sessions, or as a standalone non-invasive option for patients targeting cellular energy support, cognitive maintenance, and age-related metabolic decline. All applications are investigational and off-label.
See general NAD⁺ safety (ID 154). Intranasal administration eliminates the IV infusion-related reaction risk. Primary safety considerations are nasal mucosal irritation and ensuring the formulation excipients are well tolerated intranasally.
Common Side Effects: Nasal irritation, mild burning sensation on administration, transient rhinorrhea or congestion.
Store at room temperature (15–25°C) or as directed on the label, away from heat and light. Do not freeze. Keep the nasal tip clean; replace cap after each use. Use within the beyond-use date specified by Genesis Compounding.
Is intranasal NAD⁺ the same as IV NAD⁺?
No. Intranasal NAD⁺ provides a convenient, self-administered maintenance dose with lower and less predictable systemic levels than IV infusion. It is typically used as a maintenance regimen or a supplement to IV-based induction protocols, not as a replacement for high-dose IV therapy.
How does NAD⁺ get to the brain through the nose?
The olfactory epithelium in the upper nasal cavity has direct neural connections to the brain. Intranasal delivery exploits this pathway for potential nose-to-brain transport, which may allow higher CNS concentrations than would be achieved by systemic absorption alone.
Is this FDA-approved?
No. Intranasal NAD⁺ is not FDA-approved. This is a prescriber-directed, patient-specific 503A compounded preparation by Genesis Compounding.
How should I store the spray?
At room temperature, away from heat and direct sunlight. Clean the tip after each use. Use before the beyond-use date on the label.
Clinical References
Authoritative sources reviewed in preparing this clinical summary. Provided for prescriber reference; not a substitute for the prescriber’s clinical judgment.