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Hormone Optimization

Hormone Optimization brings together prescriber-directed therapies for sex hormone support, thyroid replacement, and related endocrine care. Products in this hub are organized around lab-guided prescribing, symptom assessment, route selection, and ongoing monitoring.

Available Medications

Medications and product segments have been placed into this hub based on their primary clinical purpose, route, and supporting evidence.

Liothyronine (T3)

Liothyronine is synthetic T3 thyroid hormone used in thyroid replacement protocols.

Liothyronine | Levothyroxine

Levothyroxine is synthetic T4 thyroid hormone used in thyroid replacement protocols.

Estriol 0.01% | Hydrocortisone 0.5% | Hydroquinone 6% | Kojic Acid 6% | Tretinoin 0.05%

Hydrocortisone is a low-potency corticosteroid used for inflammation and irritation.

Estriol 0.1% | GHK-Cu 0.5% | Hyaluronic Acid 0.5%

Hyaluronic acid is a hydrating polymer used in topical skin and wound-support formulations.

Anastrozole 0.1mg | Clomiphene 20mg | DHEA 20mg | 7-Keto DHEA 20mg | Pregnenolone 20mg

Pregnenolone is a steroid precursor used in some compounded hormone-support formulas.

Anastrozole 1mg

Anastrozole is an aromatase inhibitor used to reduce estrogen production in selected protocols.

Clomiphene 25mg

Clomiphene is a selective estrogen receptor modulator used in fertility and endocrine protocols.

Clomiphene 55mg

Clomiphene is a selective estrogen receptor modulator used in fertility and endocrine protocols.

DHEA 25/50mg (Take 1 Cap PO QAM)

DHEA is an adrenal steroid precursor used in some hormone protocols.

Enclomiphene 10mg

Enclomiphene is the trans-isomer of clomiphene used in some male testosterone optimization protocols under prescriber supervision.

Enclomiphene 12.5 mg - 28 capsules

Enclomiphene is the trans-isomer of clomiphene used in some male testosterone optimization protocols under prescriber supervision.

Enclomiphene 25mg

Enclomiphene is the trans-isomer of clomiphene used in some male testosterone optimization protocols under prescriber supervision.

T-Prime base w/enclomiphene

Enclomiphene is the trans-isomer of clomiphene used in some male testosterone optimization protocols under prescriber supervision.

Testosterone 50mg, 100mg, 150mg, 200mg (Apply 1 to 4 clicks topically QAM)

Testosterone is an androgen used in prescriber-directed hormone protocols.

Testosterone Cypionate (1000mg/5mL)

Testosterone cypionate is an injectable androgen ester used for testosterone replacement when hypogonadism is clinically confirmed.

DHEA 5/10/25mg (Take 1 Cap PO QAM)

DHEA is an adrenal steroid precursor used in some hormone protocols.

E3/E2 4/4mg/mL (Apply 1 to 2 clicks (1-2 mg) topically QAM)

Prescription-only Cream for prescriber-directed hormone optimization protocols.

Estradiol Gel 37.5gm 0.06%

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Gel 50gm 0.06%

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Patch 0.025mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Patch 0.05mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Patch 0.075mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Patch 1mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Tablet 0.5mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Tablet 1mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Tablet 2mg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Vaginal Cream 30gm 0.03%

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Vaginal Cream 42.5gm 0.01%

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Vaginal Tablet 12mcg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Estradiol Vaginal Tablet 6mcg

Estradiol is an estrogen used in hormone therapy and vulvovaginal estrogen protocols.

Ondansetron 8mg/mL

Ondansetron is a 5-HT3 receptor antagonist used for nausea/vomiting protocols.

Progesterone IR/SR 50mg, 100mg, 150mg, 200mg, 300mg (Typical SIG 50-300mg PO QHS)

Progesterone is a progestogen used in hormone therapy protocols, commonly for endometrial protection when systemic estrogen is used in a patient with a uterus.

Pyridoxine 10mg | Doxylamine 10mg | Ginger 10mg

Pyridoxine is vitamin B6.

Testosterone 12/20 mg/ml (Apply 1 click (3 or 5 mg) topically QAM)

Testosterone is an androgen used in prescriber-directed hormone protocols.

120mg / 2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

15mg / 1/4 grain

Prescription-only for prescriber-directed hormone optimization protocols.

30mg / 1/2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

60mg / 1 grain

Prescription-only for prescriber-directed hormone optimization protocols.

90mg / 1 1/2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

Estriol 0.1% | GHK-Cu 0.5% | Hyaluronic Acid 0.5%

Hyaluronic acid is a hydrating polymer used in topical skin and wound-support formulations.

TPrime365™ Sublingual Testosterone Optimization: Enclomiphene 25mg | Spermidine 10mg | Boron 10mg | Vitamin C 10mg

Testosterone is an androgen used in prescriber-directed hormone protocols.

1-30mg up to 1/2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

31-60mg up to 1 grain

Prescription-only for prescriber-directed hormone optimization protocols.

61-90mg up to 1 1/2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

91-120mg up to 2 grain

Prescription-only for prescriber-directed hormone optimization protocols.

More Medications Available

Prescription-only compounded preparation for prescriber-directed therapy.

Studies, data, and supporting evidence

These sources support the conservative educational statements on this page. They do not replace individualized medical judgment.

The 2022 Hormone Therapy Position Statement of The North American Menopause Society
Menopause · 2022

Hormone therapy remains the most effective treatment for vasomotor symptoms and genitourinary syndrome of menopause; risks vary by type, dose, duration, route, timing, and progestogen use.

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Endocrine Society Clinical Practice Guideline: Testosterone Therapy in Men With Hypogonadism
JCEM · 2018

Recommends testosterone therapy for men with symptomatic testosterone deficiency after discussion of benefits, risks, and appropriate monitoring.

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Global Consensus Position Statement on Testosterone Therapy for Women
JCEM · 2019

States the only evidence-based indication for testosterone therapy in women is hypoactive sexual desire disorder.

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DailyMed: Testosterone Cypionate Injection
NIH/NLM

Official U.S. drug labeling describes testosterone cypionate injection as an intramuscular androgen product with contraindications, warnings, and monitoring considerations.

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Micronized Progesterone and Endometrial Protection
Climacteric · 2016

Systematic review supports oral micronized progesterone for endometrial protection when used with systemic estrogen in evidence-based regimens.

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ATA Guidelines for the Treatment of Hypothyroidism
Thyroid · 2014

Levothyroxine remains standard therapy for hypothyroidism; combination therapy and desiccated thyroid require individualized clinical judgment.

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DailyMed: Levothyroxine Sodium Tablets
NIH/NLM

Official labeling includes dosing, absorption considerations, drug interactions, and boxed warning against use for weight loss.

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