Semaglutide 1mg/mL
Semaglutide 1mg/mL is a prescriber-directed weight-management medication option. It should be used as part of a broader care plan that includes nutrition, activity, contraindication screening, and monitoring.
Semaglutide 1 mg/mL is a compounded multi-dose injectable solution formulated at a concentration of 1 mg per milliliter. This concentration allows the prescriber to specify individualized weekly doses (e.g., 0.25 mg = 0.25 mL, 0.5 mg = 0.5 mL, 1.0 mg = 1.0 mL) from a single vial using a standard insulin syringe, enabling precise titration across the full dose escalation range. Genesis Compounding prepares this as a prescription-only 503A compounded preparation that is not FDA-approved as a compounded product.
| Active Ingredient | Pharmacologic Role |
|---|---|
| Semaglutide 1 mg/mL | Long-acting GLP-1 receptor agonist enabling patient-specific weekly dose titration for glycemic control and weight management at a precise 1 mg/mL concentration. |
Route: Subcutaneous injection, once weekly.
- The 1 mg/mL concentration simplifies dose calculation: the injection volume in mL equals the dose in mg (e.g., 0.5 mg = draw 0.5 mL).
- Use an insulin syringe to draw the prescribed volume. Remove air bubbles before injecting.
- Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate sites each week.
- Administer once weekly on the same day.
- Dispose of needles in a sharps container after use.
Prescriber-determined weekly dose drawn from the 1 mg/mL vial. Volume is calculated as: dose (mg) ÷ 1 mg/mL = volume to draw (mL). Titration follows standard protocols (see Semaglutide 0.5 mg and 1 mg entries). All dose adjustments require prescriber direction.
- Semaglutide: Identical mechanism to that described for semaglutide 0.5 mg (ID 182). The concentration (1 mg/mL) is a formulation parameter only; pharmacodynamics are determined by the administered dose.
Indication context and monitoring: Identical to semaglutide 0.5 mg and 1 mg entries. The 1 mg/mL concentration is a compounding convenience that allows single-vial titration from 0.25 mg through doses exceeding 1 mg per injection, reducing the need for multiple vial concentrations. Prescribers should clearly specify the exact volume to inject on each prescription.
Safety profile is identical to semaglutide in all other entries. See semaglutide 0.5 mg (ID 182) for complete contraindications, warnings, and drug interactions. Particular care is needed to avoid volume/dose confusion: always confirm prescribed volume explicitly with prescriber instructions before injecting.
Store refrigerated (2–8°C). Do not freeze. Protect from light. Once the vial is first punctured, use within the beyond-use date assigned by Genesis Compounding. Do not shake the vial. Keep out of reach of children.
Why is the concentration expressed as 1 mg/mL?
A concentration of 1 mg/mL simplifies dose calculation: your prescribed dose in milligrams equals the volume in milliliters you draw into the syringe. This reduces calculation errors and makes titration straightforward throughout the full dose escalation protocol.
How do I know how much to inject each week?
Your prescriber's prescription will specify your exact weekly dose in mg. Divide that number by 1 (since concentration = 1 mg/mL) to get the mL to draw. For example, 0.25 mg = 0.25 mL; 1.0 mg = 1.0 mL. Always confirm with your prescriber before each dose change.
Is this the same semaglutide as in Ozempic or Wegovy?
Yes, semaglutide is the same active ingredient. This compounded 1 mg/mL solution is prepared by Genesis Compounding as a patient-specific 503A preparation and is not an FDA-approved branded product.
How should I store the vial?
Store in the refrigerator (2–8°C). Do not freeze. Protect from light. Use within the beyond-use date printed on the label by Genesis Compounding. Do not use if particulate matter or unusual discoloration is present.
Clinical References
Authoritative sources reviewed in preparing this clinical summary. Provided for prescriber reference; not a substitute for the prescriber’s clinical judgment.