Sermorelin Nasal Spray — Natural Growth Hormone Stimulation

Route: Intranasal spray.

• Gently clear the nasal passages before use.
• Hold the bottle upright, insert the nozzle into one nostril while closing the other, and depress the pump while inhaling gently through the nose.
• Alternate nostrils if multiple sprays per dose are prescribed.
• Do not tilt the head back after administration—this promotes drainage to the throat and reduces mucosal contact time.
• Administer at bedtime on an empty stomach to align with the natural nocturnal GH surge.
• Wipe the nozzle clean and recap tightly after each use.

Prescriber-determined. Intranasal sermorelin dosing has not been standardized in FDA-approved labeling; prescribers extrapolate from subcutaneous dose data with adjustment for the lower bioavailability of intranasal peptide delivery. Common intranasal sermorelin preparations contain 200–500 mcg per spray; the prescriber will specify the number of sprays per dose and frequency (commonly at bedtime, 5 nights per week). All dosing and titration decisions are made by the prescribing clinician based on IGF-1 monitoring and clinical response.

• Sermorelin (intranasal): Following absorption through the nasal mucosa (olfactory epithelium and general respiratory mucosa), sermorelin enters systemic circulation and reaches the anterior pituitary. It binds GHRH receptors on somatotroph cells, activating adenylyl cyclase and increasing cAMP, which drives GH gene transcription and pulsatile GH secretion. As with subcutaneous sermorelin, the intact somatostatin feedback loop limits GH to physiologic levels. Nasal bioavailability of peptides is generally 5–20% of subcutaneous values but benefits from convenience and ease of patient acceptance.

Indication context: Intranasal sermorelin is prescribed for adult patients with age-related GH decline, mild GH insufficiency, or as an adjunct to anabolic/metabolic management programs, particularly for patients who are averse to injections. Monitoring requirements are identical to injectable sermorelin: baseline and periodic IGF-1 levels, fasting glucose, thyroid function, and body composition assessment.

Safety profile is broadly the same as for injectable sermorelin (ID 186–187). Additional nasal-specific considerations:

• Local nasal irritation, congestion, or epistaxis may occur with chronic intranasal peptide use.
• Patients with nasal polyps, septum deviation, or chronic rhinitis may have impaired and variable absorption.
• Systemic effects of supraphysiologic GH (fluid retention, arthralgias) are less likely than with subcutaneous dosing due to lower bioavailability, but remain possible.

Contraindications: Same as injectable sermorelin—active neoplastic disease, untreated hypothyroidism, and hypersensitivity to sermorelin or excipients.

Store per Genesis Compounding's dispensing label instructions (typically refrigerated at 2–8°C). Protect from light. Do not freeze. Keep the cap tightly closed between uses. Use within the beyond-use date on the label. Keep out of reach of children.

Is intranasal sermorelin as effective as the injection?

Intranasal delivery of peptides generally results in lower and more variable systemic bioavailability compared to subcutaneous injection—typically 5–20% of the injected dose reaches systemic circulation via the nasal route. Prescribers adjust the intranasal dose accordingly. Your IGF-1 level will be the primary objective measure of response, guiding dose optimization.

How should I administer the nasal spray?

Clear your nasal passages, hold the bottle upright, insert the nozzle into one nostril while closing the other, and press the pump while breathing gently through the nose. Do not tilt your head back after spraying. Administer at bedtime on an empty stomach to align with the body's natural nocturnal GH surge.

Why take sermorelin at night?

Growth hormone is primarily secreted during slow-wave sleep, approximately 1–2 hours after sleep onset. Bedtime administration of sermorelin on an empty stomach (free of carbohydrates that suppress GH release) maximizes stimulation of this natural nocturnal GH pulse.

Will chronic nasal use cause any problems?

Some patients experience mild nasal irritation or congestion with regular intranasal peptide administration. These effects are usually minor. Patients with pre-existing nasal conditions (polyps, deviated septum, chronic sinusitis) should discuss absorption reliability with their prescriber.

Is this FDA-approved?

Intranasal sermorelin is not FDA-approved. This preparation is a patient-specific 503A compounded product from Genesis Compounding prepared under a valid prescriber order.